Protein design meets biosecurity.

The power and accuracy of computational protein design have been increasing rapidly with the incorporation of artificial intelligence (AI) approaches. This promises to transform biotechnology, enabling advances across sustainability and medicine. DNA synthesis plays a critical role in materializing designed proteins. However, as with all major revolutionary changes, this technology is vulnerable to misuse and the production of dangerous biological agents. To enable the full benefits of this revolution while mitigating risks that may emerge, all synthetic gene sequence and synthesis data should be collected and stored in repositories that are only queried in emergencies to ensure that protein design proceeds in a safe, secure, and trustworthy manner.

Advancing Biomedicine with Graph Representation Learning: Recent Progress, Challenges, and Future Directions.

OBJECTIVES: Graph representation learning (GRL) has emerged as a pivotal field that has contributed significantly to breakthroughs in various fields, including biomedicine. The objective of this survey is to review the latest advancements in GRL methods and their applications in the biomedical field. We also highlight key challenges currently faced by GRL and outline potential directions for future research. METHODS: We conducted a comprehensive search of multiple databases, including PubMed, Web of Science, IEEE Xplore, and Google Scholar, to collect relevant publications from the past two years (2021-2022). The studies selected for review were based on their relevance to the topic and the publication quality. RESULTS: A total of 78 articles were included in our analysis. We identified three main categories of GRL methods and summarized their methodological foundations and notable models. In terms of GRL applications, we focused on two main topics: drug and disease. We analyzed the study frameworks and achievements of the prominent research. Based on the current state-of-the-art, we discussed the challenges and future directions. CONCLUSIONS: GRL methods applied in the biomedical field demonstrated several key characteristics, including the utilization of attention mechanisms to prioritize relevant features, a growing emphasis on model interpretability, and the combination of various techniques to improve model performance. There are also challenges needed to be addressed, including mitigating model bias, accommodating the heterogeneity of large-scale knowledge graphs, and improving the availability of high-quality graph data. To fully leverage the potential of GRL, future efforts should prioritize these areas of research.

A More Diverse and Complete Reference Human Genome Is Poised to Change Medicine.

This Medical News article discusses the Human Pangenome Project.

Introduction: Medical Mobilities in the Modern Middle East and North Africa.

This themed section contributes to efforts to conceptualize medical mobility. It does so by observing medical histories within the Middle East while following concrete movements. This focus on what moves and how, rather than on largely static and fixed units of analysis on where to, is central to the studies in this issue. The location of the Middle East, as a crossroad for imperial mobilities-is ideal for exploring transnational medical movements. Bringing together historians of the Middle East and North Africa, the articles explore intersections among medicine, health, and the body and histories of cross-regional mobility. This section spans the period from the early twentieth century to the 1970s. The articles are based on primary sources in Greek, Turkish, English, French, Spanish, and Arabic, located in the national archives of the UK, Israel, and Cyprus; in French diplomatic and military archives; and in the Overseas Nursing Association's publications.

A Thread of Life: Mahbub al-Mahmud and Medical Modernization in Early Twentieth-Century Morocco.

The medical auxiliary Mahboub al-Mahmoud (Tangier, 1888-ca. 1970) remains a neglected figure in the history of Morocco's medical modernization. However, his life and professional trajectory can provide a fruitful standpoint from which to question the persisting nationalist bias that has pervaded the modest postcolonial medical historiography about that farthest corner of North Africa. Mahboub's multiple mobilities-temporal, social, geographical, professional-transcend the "colonial fractures" created by the complex European partition of Morocco, which have resulted in Moroccans playing no significant role in the narratives of the origin and development of modern medicine in the country. This paper is divided into three sections, each of which deals with a distinctive phase of Mahboub's itinerary, his connections with various groups of irregular medical practitioners, and the modernizing initiatives they embodied from the times of Hassan I's late nineteenth-century reforms to the rise of Moroccan anticolonial nationalism in the 1930s.

Modern Medicine: Ideas and Advances.

Considering the limitations of medical science and the risks associated with medical treatments, we need to re-examine the connotation of medical science from the perspective of philosophy. Medical science is the natural expression of human kindness and human nature of rescuing the dying and healing the wounded. It is a combination of the natural sciences, social sciences, and humanities. From the perspectives of medical philosophy and humanistic care, this article expounds the concepts and ideas of evidence-based, translational, and precision medicine in modern medicine and emphasizes the importance of avoiding new technical bureaucracy, paying attention to achieving a holistic view and systematic understanding, and avoiding biases in development because of the loss of the humanistic spirit in modern medical practice.